TOP1 - Wikipedia
It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the …
TOP1 - DNA topoisomerase 1 - Homo sapiens (Human) - UniProt
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single …
The Potential of Topoisomerase Inhibitor-Based Antibody–Drug …
Here, we review the importance of TOP1 inhibitor-based ADCs (TOP1-ADCs) in cancer therapy, the current state of knowledge regarding the design of TOP1-ADCs, and TOP1-ADCs under development.
TOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody
Jan 15, 2026 · TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Hematologic Cancer and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal …
RNA interacts with topoisomerase I to adjust DNA topology
Aug 21, 2024 · Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate torsional stress during transcription. However, the mechanisms underlying the regulation of …
TDP1-independent pathways in the process and repair of TOP1
Jul 22, 2022 · Anticancer drugs, such as camptothecin (CPT), trap topoisomerase I (TOP1) on DNA and form TOP1 cleavage complexes (TOP1cc). Alternative repair pathways have been suggested in the …
Topoisomerase I in Human Disease Pathogenesis and Treatments
May 12, 2016 · Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA …
TOP1 - an overview | ScienceDirect Topics
TOP1 refers to Topoisomerase 1, a highly conserved enzyme essential for relaxing supercoiled DNA and facilitating transcription and replication processes.
Topoisomerase 1 inhibition suppresses inflammatory genes and ... - Science
We identified topoisomerase 1 (Top1) as a positive regulator of RNA polymerase II transcriptional activity at pathogen-induced genes. Depletion or chemical inhibition of Top1 suppresses the host …
Top1-PARP1 association and beyond: from DNA topology to break …
One of the most common forms of DNA damage that arise in cells are single-strand breaks (SSBs). The SSBs can occur from the abortive activity of DNA topoisomerase 1 (Top1), due to the covalent …